Nesrine Aissaoui


Nesrine Aissaoui, PhD, Post DOc

Phone: +46(0)31 772 3045
E-mail: nesrine(at)chalmers.se


Brief Bio:
I graduated my M.Sc. degree from the Department of Chemistry of the National Institute of Applied Science and Technology of Tunisia in 2009. My diploma work was performed in collaboration with the University Pierre and Marie Curie, Paris 6 in France at the Laboratory of Surface Reactivity (LRS) and it was centered in the study of biosensors, using DNA in “hairpin conformation”.
After completing my undergraduate studies, I continued my thesis at LRS under the direction of Prof. Jean-François Lambert and the supervision of Assistant Prof. Jessem Landoulsi. During my PhD, I studied the role of surface chemistry on enzyme immobilization. The interface was described by demonstrating the role of crosslinkers on enzyme properties (amount, supramolecular organization, and catalytic activity). A relevant structure-function relationship correlating the organization of the interface to the bioactivity of immobilized enzymes was established.
After obtaining my PhD degree in 2013. In April 2014, I joined to the Department of Chemical and Biological Engineering at Chalmers University of Technology as a post-doc within a research project leaded by Prof. Bo Albinsson, Prof. Mikael Käll, Prof. Kasper Moth-Poulsen and Prof. Marcus Wilhelmsson.

Current Research Activities:  
My present project joins DNA-nanotechology and plasmonic nanoparticles studies. It involves the (i) design and synthesis of DNA origami, (ii) technology development to place organic fluorophores and metal nanoparticles on the expected sites on the DNA origami platform, and (iii) investigation of photophysical measurements and theoretical developments to describe the transfer rates.

Selected Publications (last 3 years):
1.   Aissaoui, N.; Bergaoui, L.; Boujday, S.; Lambert, J.-F.; Methivier, C.; Landoulsi, J., Enzyme Immobilization on Silane-Modified Surface through Short Linkers: Fate of Interfacial Phases and Impact on Catalytic Activity. Langmuir 2014, 30, (14), 4066-4077.

2.   Aissaoui, N.; Landoulsi, J.; Bergaoui, L.; Boujday, S.; Lambert, J.-F., Catalytic activity and thermostability of enzymes immobilized on silanized surface: Influence of the crosslinking agent. Enzyme and Microbial Technology 2013, 52, (6–7), 336-343.

3.   Liascukiene, I.; Aissaoui, N.; Asadauskas, S. J.; Landoulsi, J.; Lambert, J.-F., Ordered Nanostructures on a Hydroxylated Aluminum Surface through the Self-Assembly of Fatty Acids. Langmuir 2012, 28, (11), 5116-5124.

4.   Aissaoui, N.; Bergaoui, L.; Landoulsi, J.; Lambert, J.-F.; Boujday, S., Silane Layers on Silicon Surfaces: Mechanism of Interaction, Stability, and Influence on Protein Adsorption. Langmuir 2012, 28, (1), 656-665.